Chiral Ring Generating Functions & Branches of Moduli Space

34 pages, 7 figures34 pages, 7 figures34 pages, 7 figuresWe consider the worldvolume theory of N D3-branes transverse to various non-compact Calabi-Yau spaces, and describe subtleties in the counting of chiral primary operators in such theories due to the presence of multiple branches of moduli space. Extra branches, beyond those directly related to the transverse geometry, result in additional terms in the generating functions for single- and multi-trace operators. Ideals in the N=1 chiral ring correspond to various branches and, in the large N limit, the operator counting reveals a product of Fock spaces, including the Fock space of bosons on the space transverse to the branes

Investigation into the relationship between adolescents’ perceived and actual fundamental movement skills and physical activity

Abstract Objectives: To explore the relationship between fundamental movement skill (FMS) competence, perceived FMS competence and physical activity (PA) in adolescents. Methods: The Test of Gross Motor Development (TGMD), the TGMD-2 and the Victorian Skills manual were used to assess FMS competence (locomotor, object control and stability). The Physical Self Confidence scale was used to assess perceived FMS competence (locomotor, object control and stability). Moderate to vigorous intensity PA (MVPA) was measured via accelerometry. Multi-level modelling analyses was used to examine: (i) actual FMS as the predictor and perceived FMS as the outcome, (ii) perceived FMS as the predictor and MVPA as the outcome, and (iii) actual FMS as the predictor and MVPA as the outcome. All analyses were completed for each subtest of FMS (locomotor, object control and stability). Results: A total of 584 adolescents (boys n = 278) aged 12.82 – 15.25 years (M 13.78, SD .42) participated in this study. Actual stability was associated with perceived stability (p<.01) and MVPA (p<.05) in boys. This was not found true for girls, however actual locomotor skills were associated with MVPA (p≤.05). Boys scored significantly higher than girls for FMS proficiency, perceived FMS and MVPA (p<.05). Discussion: Gender differences may exist due to cultural gender differences in sport participation norms. Considering the magnitude of physical and psychological changes occurring during adolescence, it is recommended to track young people over time to better understand the relationship between perceived and actual FMS, as well as PA participation. Keywords: physical activity, motor competence, adolescent

The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial

Low levels of physical activity in youth are an issue internationally, with the age related decline in levels over the adolescent period of particular concern. This study evaluated a multi-component school-based intervention (Y-PATH: Youth-Physical Activity Towards Health), focused on halting the age-related decline in physical activity of youth in early adolescence. A cluster randomized controlled trial in 20 post primary schools (10 control, 10 intervention) was conducted. Data were collected from all 20 schools at baseline (2013), and 12 months (2014), and from 10 of these schools (5 intervention) at 24 months (2015). The setting was mixed gender post primary schools residing in the greater area of Dublin, Ireland. Principals from each school were asked to nominate one first year class group attending their school in September 2013 to participate in the study (N = 564). Intervention schools implemented the Y-PATH whole school intervention, comprising teacher component, parent component, and PE component; while control schools continued with usual care. The main outcome measure was accelerometer derived average minutes of daily moderate to vigorous physical activity (MVPA). Data were analysed from October 2015 -November 2017. At baseline 490 participants were assessed (mean age 12.78y ± .42). Results of the multilevel regression analysis confirmed that there was a significant time intervention effect, and this was predominantly contributed by the difference between control and intervention groups within females. Findings support the case for national dissemination of the Y-PATH intervention so that the knowledge learned can be translated to routine practice in schools

Reducing delays in the diagnosis and treatment of muscle-invasive bladder cancer using simulation modelling

This is the author accepted manuscript. The final version is available from SAGE Publications via the DOI in this record Objective: To develop a simulation model to identify key bottlenecks in the bladder cancer pathway at Royal Cornwall Hospital and predict the impact of potential changes to reduce these delays. Materials and methods: The diagnosis and treatment of muscle-invasive bladder cancer can suffer numerous delays, which can significantly affect patient outcomes. We developed a discrete event computer simulation model of the flow of patients through the bladder cancer pathway at the hospital, using anonymised patient records from 2014 and 2015. The changes tested in the model were for patients suspected to have muscle-invasive disease on flexible cystoscopy. Those patients were ‘fast-tracked’ to receive their transurethral resection of bladder tumour (TURBT) treatment using operating slots kept free for these patients. A staging computed tomography scan was booked in the haematuria clinic. Pathology requests were marked as 48 hour turnaround. The nurse specialist would then speak to the patient whilst they were on the ward following their TURBT to give information about their ongoing treatment and provide support. Results: The model predicted that if the changes were implemented, delays in the system could be reduced by around 5 weeks. The changes were implemented, and analysis of 3 months of the data post-implementation shows that the average time in the system was reduced by 5 weeks. The environment created by the changes in the pathway improved referral to treatment times in both muscle-invasive and non-muscle-invasive groups. Conclusion: The simulation model proved an invaluable tool for facilitating the implementation of changes. Simple changes to the pathway led to significant reductions in delays for bladder cancer patients at Royal Cornwall Hospital. Level of evidence: Not applicable for this cohort study.National Institute for Health Research (NIHR